Synthesis of hemoglobin F in adult simian erythroid progenitor-derived colonies.
نویسندگان
چکیده
منابع مشابه
Erythroid Progenitor-derived Colonies
Address reprint requests to Dr. David G. Nathan, Children's Hospital Medical Center, Boston, MA 02115. Received for publication 6 April 1982 and in revised form 12 July 1982. in environmental erythropoietin and burst-promoting activities.
متن کاملDetermination of the hemoglobin F program in human progenitor-derived erythroid cells.
The absolute adult and fetal hemoglobin (HbF) contents of the erythroid cells derived from the differentiation of normal human and simian erythroid progenitors and of the peripheral blood erythroid burst-forming units (BFU-E) of patients with nondeletion hemoglobinopathies have been measured with a sensitive radioligand immunoassay. The HbF content varied between 0.13 and 2.96 pg/cell, represen...
متن کاملHemoglobin synthesis in human BFU-E and CFU-E-derived erythroid colonies.
We have analyzed the synthesis of fetal hemoglobin (HbF) in the differentiated erythroid colonies produced by erythropoietin-responsive committed erythroid progenitors in plasma cultures of human marrow and peripheral blood. Two independent biochemical techniques. carboxymethyl-cellulose column chromatography of 3H-leucine-Iabeled globin. and polyacrylamide gel electrophoresis of 59Fe-labeled h...
متن کاملControl of the simian fetal hemoglobin switch at the progenitor cell level.
This investigation was designed to define the cellular level at which the gamma to beta globin switch is established in the developing simian fetus in order to determine whether the switch is controlled by environmental influences within differentiating erythroid precursors or predetermined by the genetic program of erythroid progenitors. Samples of marrow and liver were obtained from rhesus fe...
متن کاملL-Arginine-Nitric Oxide Signaling Pathway Zileuton Induces Hemoglobin F Synthesis in Erythroid Progenitors: Role of
(1930 articles) Signal Transduction (1174 articles) Red Cells Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#reprints Infor...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1982
ISSN: 0021-9738
DOI: 10.1172/jci110671